Identification of anti-inflammatory constituents in Hypericum perforatum and Hypericum gentianoides extracts using RAW 264.7 mouse macrophages

► H. perforatum and H. gentianoides ethanol extracts inhibited inflammatory mediators. ► Four compounds contributed to H. perforatum's anti-inflammatory potential. ► Lipophilic fractions of H. gentianoides drastically inhibited inflammatory mediators. ► Uliginosin A and other acylphloroglucinols were active compounds in H. gentianoides.