Leishmanicidal effects of piperine, its derivatives, and analogues on Leishmania amazonensis

► Piperine and its analogue phenylamide are toxic to Leishmania amazonensis parasites. ► They cause alterations on parasite mitochondrial structure and function. ► The parasite's cell cycle and neutral lipid composition is affected by these compounds. ► Isobologram showed a synergism between these compounds on leishmanicidal effect. ► The use of both compounds together leads to a synergism on leishmanicdal effect.