Antiplasmodial and antimycobacterial cyclopeptide alkaloids from the root of Ziziphus mauritiana

► Cyclopeptides, mauritines L and M, were isolated from Ziziphus mauritiana root. ► The first X-ray study of a 13-membered ring cyclopeptide was reported. ► All amino acid units of nummularine B methiodide were found to be S configuration. ► The isolates showed potent antiplasmodial and antimycobacterial activities. ► This is the first report on the mentioned activities of the 14-membered alkaloids.