Toussaintines A-E: Antimicrobial indolidinoids, a cinnamoylhydrobenzofuranoid and a cinnamoylcyclohexenoid from Toussaintia orientalis leaves

► Metabolites of unprecedented indolidinoid, benzofuranoid and cyclohexanoid systems. ► Metabolites derived from leaves of near extinct Toussaintia orientalis (Annonaceae). ► Metabolites formed through mixed biosynthesis of N-cinnamoyl and tetraketide units. ► Metabolites with antibacterial (MIC 20-5 μg/mL) and antifungal activity at 40 μg/mL.