8,12;8,20-Diepoxy-8,14-secopregnane glycosides from roots of Asclepias tuberosa and their effect on proliferation of human skin fibroblasts

► Twenty-one compounds were obtained from the roots of Asclepias tuberosa. ► These compounds were 8,12;8,20-diepoxy-8,14-secopregnane glycosides. ► Some pregnane glycosides promoted the proliferation of human skin fibroblasts.