Anticancer activity of natural cytokinins: A structure-activity relationship study

This report describes the first systematic structure-activity relationship study of cytokinin anticancer activity against a diverse panel of human cancer cell lines. Analysis of the activity of the most effective cytokinin, ortho-topolin riboside, against NCI60 cell panel suggests that its mechanism of action differs from that of the standard antineoplastics. The synthesis of new cytokinin nucleotides is also described.