Phenolic analogs of the N,C-coupled naphthylisoquinoline alkaloid ancistrocladinium A, from Ancistrocladus cochinchinensis (Ancistrocladaceae), with improved antiprotozoal activities

► Isolation of the first phenolic N,8′-coupled naphthylisoquinoline alkaloids. ► Structure elucidation was achieved by modern techniques. ► 4′-O-Demethylancistrocladinium A shows excellent antitrypanosomal activity.