Phylogeny, topology, structure and functions of membrane-bound class III peroxidases in vascular plants

► Membrane-bound peroxidases were indicated by experimental data and in silico analysis. ► Orthologs and phylogenic relations of maize peroxidases are analyzed. ► Evidence for a localisation of class III peroxidases in microdomains is presented. ► Hypothetical models of membrane-bound isoenzymes showed a high structural conservation. ► The data at hand suggest essential functions of membrane-bound peroxidases in oxidative stress. ► Comparison with animal thyroid peroxidase points to a general function in membrane protection.