Cytotoxic, anti-proliferative and antimicrobial furanoditerpenoids from Stuhlmania moavi

The furanoditerpenoids voucapane (1), voucapane-6a,7a-diol (2), voucapane-18,19-diol (3) and 18-hydroxyvoucapan-19-al (4) were isolated from the cytotoxic stem and root bark extracts of Stuhlmaniamoavi Verdc. (Ceasalpiniaceae), and exhibited anti-proliferative, cytotoxic, antibacterial and antifungal activities. Some of the results thus corroborated the traditional medicinal uses of the crude extracts for the treatment of skin infections.