Tiglicamides A-C, cyclodepsipeptides from the marine cyanobacterium Lyngbya confervoides

Cyclodepsipeptides, tiglicamides A-C, were isolated from a marine cyanobacterium. They inhibited a mammalian elastase in vitro (IC50 2.14-7.28 μM). These compounds are analogues of co-produced largamides A-C and their simultaneous isolation suggests that a biosynthetic enzyme with unusually relaxed substrate specificity may be operating in this cyanobacterium.