Potential anti-inflammatory diterpenoids from the roots of Caesalpinia mimosoides Lamk.

Anti-inflammatory assay-guided separation of extracts from the roots of Caesalpinia mimosoides Lamk. led to isolation of seven compounds: four diterpenes (1-4), a dimer (9), and two dibenzo[b,d]furans (10, 11) together with eleven known compounds. Compound 4 exhibited potent inhibitory activity against LPS-induced NO production and TNF-α release in RAW264.7 cell lines with IC50 values of 3.0 and 6.5 μM, respectively.