Triterpenoidal alkaloids from Buxus hyrcana and their enzyme inhibitory, anti-fungal and anti-leishmanial activities

Phytochemical studies on the methanolic extract of Buxus hyrcana resulted in isolation of three triterpenoidal alkaloids, 17-oxo-3-benzoylbuxadine (1), buxhyrcamine (2), and 31-demethylcyclobuxoviridine (3), along with 16 known compounds. Structures of these compounds were elucidated with the aid of extensive NMR spectroscopic studies. All of the compounds exhibited moderate acetylcholinesterase, butyrylcholinesterase and glutathione S-transferase inhibitory, anti-fungal and anti-leishmanial activities.