کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5166291 | 1380103 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structure-activity studies on the lycorine pharmacophore: A potent inducer of apoptosis in human leukemia cells
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Structure-activity studies on the lycorine pharmacophore: A potent inducer of apoptosis in human leukemia cells Structure-activity studies on the lycorine pharmacophore: A potent inducer of apoptosis in human leukemia cells](/preview/png/5166291.png)
چکیده انگلیسی
The direct chemoselective differential functionalization of the ring-C hydroxyl groups present in the Amaryllidaceae alkaloid lycorine is described allowing for selective manipulation of the 1,2-hydroxyl groups. A mini-library comprised of synthetic and natural lycorane alkaloids was prepared and their apoptosis-inducing activity investigated in human leukemia (Jurkat) cells. Further insights into the nature of this interesting apoptosis-inducing pharmacophore are described, including the requirement of both free hydroxyl groups in ring-C.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Phytochemistry - Volume 70, Issue 7, May 2009, Pages 913-919
Journal: Phytochemistry - Volume 70, Issue 7, May 2009, Pages 913-919
نویسندگان
James McNulty, Jerald J. Nair, Jaume Bastida, Siyaram Pandey, Carly Griffin,