Bis-sesquiterpenes and diterpenes from Chloranthus henryi

Four bis-sesquiterpenes and three diterpenes were isolated from roots of Chloranthus henryi. Compounds 1, 5, 6 and 7 showed moderate hepatoprotective activities against d-galactosamine-induced toxicity in WB-F344 rat hepatic epithelial stem-like cells with IC50 values of 0.19, 0.66, 0.09 and 0.18 μM, respectively. Moreover, compounds 3 and 5 showed cytotoxic activities against BEL-7402, HCT-8, and BGC-823 cells.