Metabolism of (−)-grandisin from Piper solmsianum in Coleoptera and Lepidoptera species

The major tetrahydrofuran lignan grandisin from leaves of Piper solmsianum was mono- and di-O-demethylated during the digestive process of the beetle Naupactus bipes as well as in the caterpillars Heraclideshectorides and Quadrus u-lucida. Additionally, 3-hydroxy-4,5-dimethoxycinnamyl and 3,4,5-trimethoxycinnamyl alcohols were identified in the fecal extracts of N. bipes.