Iridoid glycosides from Gardeniae Fructus for treatment of ankle sprain

Eight iridoid glycosides, including genipin 1-O-β-d-isomaltoside (1), genipin 1,10-di-O-β-d-glucopyranoside (2), and geniposide (4) were isolated from the EtOH extract of Gardeniae Fructus. Geniposide (4) showed significant effects on treatment of ankle sprain in a rat model.