Dibenzofuran and pyranone metabolites from Hypericum revolutum ssp. revolutum and Hypericum choisianum

Fractionation of the dichloromethane extract of Hypericum revolutum ssp. revolutum and the hexane extract of Hypericum choisianum led to the isolation of two compounds, 3-hydroxy-1,4,7-trimethoxydibenzofuran (1) and 4-(3-O-3″)-3″-methylbutenyl-6-phenyl-pyran-2-one (2), respectively. The minimum inhibitory concentration (MIC) of (1) against a panel of multidrug- and methicillin-resistant Staphylococcus aureus strains was 256 μg/ml.