Isolation and functional analysis of two Cistus creticus cDNAs encoding geranylgeranyl diphosphate synthase

Cistus creticus ssp. creticus is an indigenous shrub of the Mediterranean that secretes from its leaves' glandular trichomes labdane-type diterpenes which exhibit cytotoxic and cytostatic activity against human cancer cell lines. GGDPS enzyme synthesizes the precursor molecule of all diterpenes. Two CcGGDPS cDNAs were cloned and characterized in this communication.