Biotransformation of myrislignan by rat liver microsomes in vitro

Myrislignan (1) is a major acyclic neolignan in seeds of Myristica fragrans. We investigated the biotransformation of myrislignan by rat liver microsomes in vitro. Seven metabolites were produced by rat liver microsomes from phenobarbital sodium-pretreated rats. As determined by spectroscopic methods, these were identified as myrislignanometins A-G (2-8).