Trypanocidal tetrahydrofuran lignans from Peperomia blanda

Five tetrahydrofuran lignans were isolated from the aerial parts of Peperomia blanda, of which compounds 1-4 are diastereomeric lignans while 5 is a novel compound. The trypanocidal activities of 1-5 were evaluated against epimastigotes of Trypanosoma cruzi strain Y.