Flavones from Struthiola argentea with anthelmintic activity in vitro

Bioassay-guided fractionation of Struthiola argentea (Thymelaeaceae) led to the isolation of three anthelmintic flavones 1-3, including the flavone 5,6,2′,5′,6′-pentamethoxy-3′,4′-methylenedioxyflavone (3). The flavone 3 exhibited the most potent in vitro activity against Haemonchus contortus with 90% inhibition of larval motility (EC90) at 3.1 μg/mL.