Anti-staphylococcal acylphloroglucinols from Hypericum beanii

Bioassay-guided fractionation of the dichloromethane extract of Hypericum beanii (Guttiferae) led to the isolation of a mixture of two acylphloroglucinols (1 and 2), 1,7-dihydroxyxanthone, stigmasterol, catechin and shikimic acid. The minimum inhibitory concentration (MIC) values of the acylphloroglucinol mixture and xanthone against multidrug-resistant Staphylococcus aureus strains ranged from 16-32 μg/ml to 128-256 μg/ml, respectively.