The prediction of isotopic patterns in phenylpropanoids from their precursors and the mechanism of the NIH-shift: Basis of the isotopic characteristics of natural aromatic compounds

The deuterium patterns (the relative abundances of isotopomers) of natural aromatic compounds are determined by that of their precursors in the shikimic acid pathway - erythrose, PEP and NADPH - and by intramolecular (IIE) and kinetic (KIE) isotope effects accompanying the NIH-shift during hydroxylation by monooxygenases.