Bioactive flavonoids and saponins from Climacoptera obtusifolia

Two bidesmosidic saponins were isolated from Climacoptera obtusifolia and their structures were determined as glucosides of gypsogenin (1) and hederagenin (2), by spectroscopic methods. Compounds 3 and 4 were identified as a known flavonoids which showed strong inhibitory activity on neutrophil oxidative burst response. Compound 2 significantly suppressed (92%) the ROS generation on the mononuclear cells 50 μg/mL concentration.