An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum

Bioautography-led isolation of an extract of the fermentation of the mitosporic fungus Acremonium crotocinigenum resulted in the characterisation of the fusidane triterpene related to fusidic acid, 1, as the major anti-staphylococcal natural product. Against efflux strains, 1 had MIC values of 16 μg/ml.