Rourinoside and rouremin, antimalarial constituents from Rourea minor

Bioassay-directed fractionation of the CHCl3 extract of the dried stems of Rourea minor (Gaertn.) Aubl. (Connaraceae) liana led to the isolation of two glycosides, rourinoside (1) and rouremin (2), as well as five known compounds. Compounds 1-3 showed weak in vitro activities against Plasmodium falciparum. Their structures and stereochemistry were elucidated by spectroscopic methods and selected enzyme hydrolysis.