Ent-kaurane glycosides and sesquiterpene lactones of the hirsutinolide type from Vernonia triflosculosa

Three hirsutinolides, three diterpenes from the ent-kaurane type, including two diterpenoid glycosides as well as two flavonoids were isolated from aerial parts of Vernonia triflosculosa. Up to now, there have been only three reports on diterpenes in the tribe Vernonieae and one in the large genus Vernonia. The effects of two hirsutinolides on the transcription factor NF-κB and on IL-8 production were studied.