Four new sesquiterpene polyol esters from Celastrus angulatus

- More information about the chemical constituents of Celastrus angulatus were given.
- Four new sesquiterpene polyol esters were discovered from Celastrus angulatus.
- The new sesquiterpene polyol esters were identified as β-dihydroagarofuran sesquiterpene.

Celastrus species, such as Celastrus angulatus, has been demonstrated to be very rich in natural sesquiterpene polyol esters sharing the β-dihydroagarofuran skeleton, some of which showed various biological activities. In this paper, four new sesquiterpene polyol esters, named as angulatins K-N (1-4), along with three known ones, 1β-acetoxy-9β-benzoxy-4α, 6α-dihydroxy-8α, 15-diisobutanoyloxy-2β-(α-methyl)-butanoyloxy-β-dihydroagarofuran, angulatin A, and celangulin III, were isolated from the root bark of C. angulatus. The structures of the new compounds were elucidated by extensive spectroscopic methods, mainly including HR-MS and 1D and 2D NMR techniques.

Four new sesquiterpene polyol esters with β-dihydroagarofuran skeleton were isolated from the root bark of Celastrus angulatus. The structures of these new compounds were elucidated on the basis of extensive spectroscopic analyses.