Chromatographic profiling and identification of two new iridoid-indole alkaloids by UPLC-MS and HPLC-SPE-NMR analysis of an antimalarial extract from Nauclea pobeguinii

► Characterisation of the total stem bark extract of Nauclea pobeguinii by UPLC-MS and HPLC-SPE-NMR. ► Two new iridoid-indole alkaloids: naucleidinic acid and 19-O-methyl-3,14-dihydroangustoline. ► Identification of strictosamide, 8 known iridoid-indole alkaloids, and a phenol glycoside.