Novel isolation of acetophenone derivatives with spiroketal-hexosefuranoside in Upuna borneensis

► The isolated products were the first instance of naturally occurring spiroketal-hexosefuranosides of acetophenone. ► The leaves of Upuna borneensis contain acetophenone C-glycosides. ► Co-occurrence of biogenetically related phloroacetophenone C-glycosides was exhibited.