Biologically active abietane and ent-kaurane diterpenoids and other constituents from Erythroxylum suberosum

► Brine shrimp toxicity guided investigation of extracts of the branches of Erythroxylum suberosum. ► Three new abietanes and one ent-kaurane were isolated from the bioactive fractions. ► Another bioactive ent-kaurane was first isolated from a natural source. ► Abietane-type diterpenes are first reported in the genus Erythroxylum. ► Two known inactive flavonoid glycosides were obtained from the leaves and branches.