کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5177203 1380852 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Unusual lipids and acylglucosylsterols from the roots of Livistona chinensis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Unusual lipids and acylglucosylsterols from the roots of Livistona chinensis
چکیده انگلیسی

A 70% ethanol extract from the roots of Livistona chinensis has been investigated, led to the isolation of 18 compounds, including two new 6′-O-acyl-β-d-glucosyl-β-sitosterols, 6′-O-(2″-hydroxyheptadecanoyl)-β-d-glucosyl-β-sitosterol (1) and 6′-O-(icosa-9″Z,12″Z-dienoyl)-β-d-glucosyl-β-sitosterol (2), two new keto esters, ethyl 16-(dodeca-4″′Z,7″′Z-dienyl)-29-oxo-15-(tetradeca-5″Z,8″Z,11″Z-trienyl) triacontanoate (7), and 16-hydroxy-8-oxohexadecyl tetradecanoate (9), a new unsaturated fatty acid, tetracosa-(11Z,14Z,18Z)-trienoic acid (8), as well as a new fatty alcohol, 10-decylnonadecane-1,19-diol (10). The structures of new compounds were elucidated, based on spectroscopic and chemical methods. The antiproliferative activity against four human tumor cell lines (K562, HL-60, HepG2, and CNE-1) was evaluated. Four compounds (1-3, 5) showed potent antiproliferative effects with the IC50 of 10-100 μM. To our knowledge, this is the first report of the occurrence of 6′-O-acyl-β-d-glucosyl-β-sitosterol and 3-O-acyl-β-sitosterol in the genus Livistona. Keto fatty acids and their esters are also rare in higher plant.

.Highlights► Eighteen lipids were isolated from the roots of Livistona chinensis. ► Six compounds are new, and eight are first time isolated from the genus Livistona. ► Four compounds (1-3, 5) showed potent antiproliferative effects. ► Keto fatty acids and their esters are rare in higher plant.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Phytochemistry Letters - Volume 6, Issue 1, February 2013, Pages 36-40
نویسندگان
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