Steroidal saponins from the rhizomes and roots of Smilax scobinicaulis

Two new spirostane-type steroidal saponins, named smilscobinosides A (1) and B (2), together with a known congener (3), have been isolated from the EtOH extract of the rhizomes and roots of Smilax scobinicaulis. The structures of the new compounds were determined by means of chemical evidence and 1D- and 2D-NMR spectroscopic analysis, FABMS and HRESIMS.

Two new steroidal saponins, smilscobinosides A (1) and B (2), were isolated from the rhizomes and roots of Smilax scobinicaulis. Their structures were elucidated on the basis of spectroscopic data and chemical transformations.Highlights► Two new steroidal saponins, smilscobinosides A and B, were isolated from Smilax scobinicaulis. ► The structures of the new compounds were determined by means of chemical evidence and 1D- and 2D-NMR spectroscopic analysis. ► (25S)-5α-Spirostan-3β, 27-diol is a new sapogenin.