کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5177393 | 1380857 | 2012 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Sesquiterpene lactones from Inula cappa Sesquiterpene lactones from Inula cappa](/preview/png/5177393.png)
Three new germacranolides, ineupatolides A-C (1-3), together with six known sesquiterpenoids, were isolated from the aerial parts of Inula cappa (Buch.-Ham.) DC. The structures of new compounds were elucidated by 1D-, and 2D-NMR techniques including HMQC, HMBC, 1H-1H COSY and ROESY spectra. The known compounds were identified by spectroscopic data analyses and data comparison. Compound 2 was finally proved to be converted from 1 with the trace existence of acid. Compounds 2 and 5 showed moderate inhibitory activity against human leukemia cell line HL-60, while compounds 2, 5, 6, 7 and 9 exhibited no antiproliferative activities on human lung cancer cell line A549.
Three new germacranolide sesquiterpenes (1-3) and six known analogues were isolated from Inula cappa, and their structures were elucidated by detailed analyses of MS, 1D-, and 2D-NMR spectroscopic data. A chemical conversion took place between compounds 1 and 2 in the presence of acid.Highlights⺠Three new germacrane-type sesquiterpenes were reported from Inula cappa. ⺠Structural elucidations were carried out by analyzing spectroscopic data. ⺠A chemical conversion took place between compounds 1 and 2 with the existence of acid. ⺠No compounds showed antiproliferative activity on human lung cancer cell line A549.
Journal: Phytochemistry Letters - Volume 5, Issue 3, September 2012, Pages 639-642