A new steroidal saponin from Allium ampeloprasum var. porrum with antiinflammatory and gastroprotective effects

A new steroidal saponin was isolated from the bulbs of Allium ampeloprasum var. porrum. On the basis of chemical conversions and detailed analyses of 1H and 13C NMR spectra including 2D NMR spectroscopic techniques, its structure was established as 3-[(O-β-d-glucopyranosyl-(1 → 3)-β-d-glucopyranosyl-(1 → 2)-O-[O-β-d-glucopyranosyl-(1 → 3)]-O-β-d-glucopyranosyl-(1 → 4)-β-d-galactopyranosyl)oxy]-2,6-dihydroxy-(2α,3β,5α,6β,25R)-spirostane. Results of the present study indicated that the steroidal saponin showed haemolytic effects in the in vitro assays and demonstrated antiinflammatory activity and gastroprotective property using in vivo models.

A new steroidal saponin was isolated from the bulbs of Allium ampeloprasum var. porrum. Its structure was established by spectroscopic techniques and chemical conversions. The steroidal saponin exhibited significant antiinflammatory and gastroprotective activities.Highlights► New steroidal saponin was isolated from Allium ampeloprasum var. porrum. ► The structure was established by spectroscopic techniques and chemical conversions. ► The compound exhibited significant antiinflammatory and gastroprotective activities.