Turrianes from Kermadecia rotundifolia as new acetylcholinesterase inhibitors

Four new kermadecins (1-4), together with kermadecins A, B and D (5-7) were isolated from the bark of Kermadecia rotundifolia. The structures of 1-4 were elucidated by spectroscopic methods and through comparison with data reported in the literature. Isokermadecin D (2) and kermadecins D and J (7 and 4) possess significant inhibitory effect on acetylcholinesterase.