Modulation of isoniazid susceptibility by flavonoids in Mycobacterium

The flavonoids epicatechin, isorhamnetin, kaempferol, luteolin, myricetin, quercetin, rutin and taxifolin were assessed for their ability to modulate isoniazid susceptibility in fast-growing mycobacteria. Myricetin was the most potent compound and could reduce the minimum inhibitory concentration of isonizid 64-fold at a concentration of 16 μg/ml.