Immunomodulatory effect of Juglans sinensis, Psoralea corylifolia, Cheong-a-hwan extract and cyclosporine A on Th1(IFN-γ)/Th2(IL-4) cytokine balance, eosinophil accumulation in a murine model of asthma

Juglans sinensis Dode (family, Juglandaceae), Psoralea corylifolia Linn. (family, Fabaceae), and Cheong-a-hwan have profound inhibitory effect on the accumulation of eosinophills into airways and blood. Also, they upregulated the production of OVA-specific Th1 cytokine (IFN-γ) and downregulated OVA-specific Th2 cytokine (IL-4) in culture supernatant of spleen cells. These results indicate that those herbal medicines may be a potential novel therapeutic agent for asthma by modulating the relationship between Th1/Th2 cytokine balance.