کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5177591 1502476 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Facile preparation of degradable thermoresponsive polymers as biomaterials: Thermoresponsive polymers prepared by radical polymerization degrade to water-soluble oligomers
ترجمه فارسی عنوان
آماده سازی چسبندگی پلیمرهای گرماسپسمی قابل تجزیه به عنوان مواد بیولوژیکی: پلیمرهای ترمورسپونزی که توسط پلیمریزاسیون رادیکال تهیه می شوند، تجزیه می شوند تا الیگومر های محلول در آب
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی


- Poly(2-methylene-1,3-dioxepane-co-2-hydroxyethyl acrylate) was synthesized.
- The prepared polymers showed thermoresponsive liquid-liquid phase separation.
- The polymer degraded to become water-soluble oligomers without thermoresponse.

A novel thermoresponsive and biodegradable polymer, poly(MDO-co-HEA), was prepared by radical copolymerization of 2-methylene-1,3-dioxepane (MDO) and a hydrophilic vinyl monomer, 2-hydroxyethyl acrylate (HEA), in dimethylsulfoxide (DMSO), varying feed monomer compositions. Poly(MDO-co-HEA) showed lower critical solution temperature (LCST)-type phase separation in aqueous medium, forming coacervate droplets into which low molecular weight hydrophobic molecules could be loaded above the LCST. The LCST could be controlled not only by the chemical compositions of the hydrophobic MDO and hydrophilic HEA in the polymer chains, but also by ion and polymer concentration. Degradation tests in aqueous media indicated that poly(MDO-co-HEA) was converted into hydrophilic oligomers by hydrolysis of the ester groups in the polymer backbone. The facile preparation poly(MDO-co-HEA) are valuable for use in functional biomedical materials, such as base of drug delivery carrier and cell culture scaffold instead of non-degradable stimuli-responsive polymer.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer - Volume 130, 9 November 2017, Pages 68-73
نویسندگان
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