کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5178564 1502497 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polymer-decorated anisotropic silica nanotubes with combined shape and surface properties for guest delivery
ترجمه فارسی عنوان
نانولوله های سیلیکا آنیزوتروپیک با پوشش پلیمری با خواص ترکیبی و خواص سطحی برای تحویل مهمان
کلمات کلیدی
نانوکامپوزیت نانسیوتروپیک، سیلیکا / پلیمر هیبرید، انتشار کنترل شده،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی


- The anisotropic nanocontainer with high aspect ratio and diblock copolymer decoration on surfaces exhibited enhanced activities from release dynamics and cellular cytotoxicity test.
- The binding affinity of nanocontainers to cell membranes was studied through free energy calculations.

We report on amphiphilic diblock copolymer-decorated anisotropic silica nanotubes with well-defined dual functions of shape and surface properties in one nanocontainer. Amphiphilic poly(lactic acid)-block-poly(ethylene glycol) (PLA-b-PEG) diblock copolymers are covalently grafted to the surface of mesoporous silica nanotubes via silane chemistry and esterification. The released percentage of probe molecules from the resultant silica-g-(PLA-b-PEG) hybrid nanocontainer is around 40% over a release time of 48 h, in contrast to 90% from bare silica nanotubes prior to surface modification. The diblock copolymer-decorated anisotropic nanocontainers with large aspect ratio lead to enhanced viability of NIH 3T3 fibroblast cells. A theoretical model based on the free energy cost for cell membranes to encapsulate nanocontainers is utilized to understand the cytotoxicity. This work demonstrates that the release dynamics of the active molecules and the interaction of hybrid nanocontainers with cell membranes can be regulated by the synergistic effect of nanocontainer shape and surface properties.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer - Volume 109, 27 January 2017, Pages 332-338
نویسندگان
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