Morphology and immunological activities of genistein-modified poly(ethylene glycol) diacrylate networks

- Genistein/PEGDA gel was photopolymerized for the first time for wound dressing.
- Phase diagram of genistein/PEGDA blend was established to guide photo-curing.
- Genistein/PEGDA gels showed improved biological activities for wound healing.

By virtue of well-known antioxidant, anti-inflammatory, and antibacterial activities, a phytochemical called 'genistein' is incorporated into polymer network membrane for wound dressing. Binary phase diagram of genistein/polyethylene glycol diacrylate precursor (PEGDA) blends was established both experimentally and theoretically. It was found that genistein crystals developed in the matrix of the PEGDA network, especially at high genistein contents. Biological activities including cytotoxicity, antioxidant, and anti-inflammatory of the networks were evaluated. The genistein-modified PEGDA network revealed improved antioxidant and anti-inflammatory functions desirable for multifunctional wound dressing.

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