کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5179406 1502524 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fabrication and characterization of a glucose-sensitive antibacterial chitosan-polyethylene oxide hydrogel
ترجمه فارسی عنوان
ساخت و مشخص نمودن یک کیتوزان آکاسیا ضد باکتری حساس به گلوکز هیدروژل پلی اتیلن اکسید
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی


- A new glucose-sensitive chitosan-polyethylene oxide (CS-PEO) hydrogel system for controlled release of antibiotics was developed.
- The mechanical property and biocompatibility of the hydrogel was enhanced with increasing PEO concentration.
- This hydrogel showed higher drug release and greater ability to inhibit Porphyromonas gingivalis at higher glucose concentration.

A novel glucose-sensitive chitosan-polyethylene oxide (CS/PEO = 1:0.5-1:2.5) hydrogel with controlled release of metronidazole (MNZ) was obtained by chemical cross-linking and immobilization of glucose oxidase (GOx). The hydrogel was characterized by Fourier-transformed infrared spectroscopy (FTIR), compressive mechanical test, rheological analysis, cytotoxicity test, and antibacterial test against Porphyromonas gingivalis. The study found that the CS-PEO composite hydrogel possessed significantly better mechanical properties and biocompatibility than a single-component hydrogel. This might result from the physical cross-linking and formation of semi-interpenetrating network (semi-IPN). In addition, this novel hydrogel has a self-regulating ability to release MNZ in response to the environmental glucose stimulus. Specifically, it released more drugs at higher glucose concentration, thus can lead to a greater ability to inhibit P. gingivalis. This study has demonstrated the glucose-sensitive antibacterial hydrogel has a great potential as a new therapeutic material for treatment or prevention of periodontitis in diabetic patients.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer - Volume 82, 15 January 2016, Pages 1-10
نویسندگان
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