کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5183553 1381022 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
pH/temperature-sensitive 4-arm poly(ethylene glycol)-poly(amino urethane) copolymer hydrogels
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
pH/temperature-sensitive 4-arm poly(ethylene glycol)-poly(amino urethane) copolymer hydrogels
چکیده انگلیسی

A series of novel pH/temperature-sensitive 4-arm poly(ethylene glycol)-poly(amino urethane) copolymers was synthesized via addition polymerization. The resulting copolymers were characterized by 1H, 13C NMR, Fourier transform infrared spectroscopy and gel permeation chromatography. Poly(amino urethane) (PAU) segment acts as a pH/temperature-sensitive block. The copolymer aqueous solutions showed a sol-to-gel-to-aggregation phase transition as a function of pH and temperature when the pH of the copolymer solution is higher than 6.8. The sol-gel phase transition could be controlled by varying the PAU block length and copolymer concentration. The gel window covers the physiological conditions and a white gel was formed rapidly after subcutaneously injecting the copolymer solution (30 wt%) into SD rats. The in vitro release of chlorambucil, an anticancer drug, was sustained over 14 days under physiological conditions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer - Volume 51, Issue 17, 4 August 2010, Pages 3843-3850
نویسندگان
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