کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5183985 | 1381035 | 2010 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis and physical gels of pH- and thermo-responsive tertiary amine methacrylate based ABA triblock copolymers and drug release studies Synthesis and physical gels of pH- and thermo-responsive tertiary amine methacrylate based ABA triblock copolymers and drug release studies](/preview/png/5183985.png)
A series of novel pH-responsive ABA triblock copolymer gelators have been synthesized by using poly[2-(diisopropylamino)ethyl methacrylate] (PDPA) as the A block and poly[2-(dimethylamino)ethyl methacrylate] (PDMA) as the B block via group transfer polymerization. While the PDPA-b-PDMA-b-PDPA triblock copolymers are molecularly soluble in acidic aqueous media due to protonation of all tertiary amine groups, they formed either gels by the chain-end hydrophobic interactions with relatively high polymer concentration (10Â wt%) or near monodisperse “flower” micelles with low polymer concentration at neutral and basic aqueous solutions. The hydrophobic model drug release was studied in a sustained manner from the gels at pH 7.4 by varying the polymer concentration, the polymer molecular weight and the temperature of the medium. Preliminary studies indicate that both slow, sustained release and fast, triggered release of a model hydrophobic drug, dipyridamole, can be achieved by tuning the solution pH, polymer concentration, polymer molecular weight and temperature of the gel.
Journal: Polymer - Volume 51, Issue 16, 22 July 2010, Pages 3618-3626