کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5184366 | 1381045 | 2010 | 7 صفحه PDF | دانلود رایگان |
We perform dynamical Monte Carlo simulation to study the forced translocation of compact polymer chains in three-dimensional lattices. The chains are driven through a nanopore connecting two infinite channels by an external field. The scaling properties of average translocation time Ï and translocation time distribution (TTD) are studied. The effects of contact energy (ÉC), electric field strength (E), and nanopore width (L) on the scaling exponent (α) of average translocation time Ï â¼Â Nα and the TTD are investigated. For the scaling behavior of Ï â¼Â Nα, we have found that there is no crossover behavior with weak field strength when the nanopore width is one lattice spacing, which is less than average bond length, while crossover behaviors are observed for larger nanopore widths. The scaling exponent α also depends on contact energy ÉC and electric field strength E. For the TTD, it shifts from the Gaussian to a right-skew distribution with the electric field E increasing for short chains; while for long chains, multi-peak distributions are observed. As a primary and simple model, compact polymer chains are extensively used to capture the structure and thermodynamic properties of proteins, therefore we can investigate the protein translocation by simulating compact chain translocation, and this study will be useful for exploring the complex translocation behaviors of proteins.
Journal: Polymer - Volume 51, Issue 12, 28 May 2010, Pages 2795-2801