کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5185191 1381070 2010 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Double-brush Langmuir-Blodgett monolayers of α-helical diblock copolypeptides
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Double-brush Langmuir-Blodgett monolayers of α-helical diblock copolypeptides
چکیده انگلیسی

The synthesis of amphiphilic diblock copolypeptides consisting of poly(α-l-glutamic acid) (PLGA) and poly(γ-methyl-l-glutamate-ran-γ-stearyl-l-glutamate) with 30 mol % of stearyl substituents (PMLGSLG) and their monolayer behavior at the air-water interface have been studied. PLGA-b-PMLGSLG was synthesized via a diblock copolymer precursor consisting of poly(γ-tert-butyl-l-glutamate) (PtBuLG) and PMLGSLG blocks, with the tert-butyl group as a mild acid-labile protecting group for the carboxylic acid. The polymerization conditions were found to influence the α-helix to β-sheet content ratio and can be tuned to significantly enhance the diblock copolypeptide helicity. Purely α-helical PtBuLG-b-PMLGSLG diblock copolymers were successfully prepared. After removal of the tert-butyl group, the study of the PLGA-b-PMLGSLG amphiphilic diblock copolymers in Langmuir monolayers and Langmuir-Blodgett films demonstrated the formation of a stable α-helical double-brush structure, with the helices tilted away from the substrate surface. These double-brush monolayers combine the unique properties arising from the unidirectionally aligned helix macrodipole and the liquid-like features of the side chain mantle of the PMLGSLG block. Such systems are promising for thin film applications requiring incorporation and orientation of bio- and optical molecules.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer - Volume 51, Issue 5, 2 March 2010, Pages 1042-1055
نویسندگان
, , , , ,