کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5185567 1381081 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Schizophrenic copolymer from natural biopolymer by facile grafting
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Schizophrenic copolymer from natural biopolymer by facile grafting
چکیده انگلیسی

A novel schizophrenic copolymer responsive to pH and temperature change was developed through copolymerization of N-isopropylacrylamide (NIPAm) and acrylic acid (AA) on chitosan chains by a bio-friendly initiator. The behavior of purified graft copolymer in solution phase was studied in detail by NMR, Zetasizer, TEM, SEM and ATR-FTIR techniques. In dilute aqueous media, two types of reversible nanoparticles can be obtained by changing temperature and pH: positively charged micelles with chitosan-shell in acidic solutions above 33 °C and negatively charged micelles with P(NIPAm-co-AA)-shell in alkaline solutions. The transform between these two oppositely charged micelles can be easily controlled by changing pH at human body temperature. The effect of graft degree on the solution behavior was also studied. This novel schizophrenic copolymer has potential applications in drug delivery and other controlled releases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer - Volume 51, Issue 4, 15 February 2010, Pages 890-896
نویسندگان
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