|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5186015||1381093||2009||6 صفحه PDF||سفارش دهید||دانلود رایگان|
Poly(Î³-benzyl l-glutamate)-block-poly(l-phenylalanine) was prepared via the ring opening polymerization of Î³-benzyl l-glutamate N-carboxyanhydride and l-phenylalanine N-carboxyanhydride using n-butylamineÂ·HCl as an initiator for the living polymerization. Polymerization was confirmed by 1H-nuclear magnetic resonance spectroscopy and matrix assisted laser desorption ionization time of flight mass spectroscopy. After deprotection, the vesicular nanostructure of poly(l-glutamic acid)-block-poly(l-phenylalanine) particles was examined by transmission electron microscopy and dynamic light scattering. The pH-dependent properties of the nanoparticles were evaluated by means of Î¶-potential and transmittance measurements. The results showed that the block copolypeptide could be prepared using simple techniques. Moreover, the easily prepared PGA-PPA block copolypeptide showed pH-dependent properties due to changes in the PGA ionization state as a function of pH; this characteristic could potentially be exploited for drug delivery applications.
Journal: Polymer - Volume 50, Issue 10, 8 May 2009, Pages 2252-2257