کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5186279 1381100 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and degradation of poly(beta-aminoester) with pendant primary amine
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and degradation of poly(beta-aminoester) with pendant primary amine
چکیده انگلیسی

Three poly(beta-aminoester)s with pendant primary amines were synthesized by Michael addition of N-Boc-protected diamine to 1,4-butanediol diacrylate, followed by removal of N-Boc-protective group under anhydrous acidic conditions. The degradation rate of poly(beta-aminoester)s with pendant primary amines is dependant on their side-chain structures and pH value of incubation buffer. The degradation in basic environments is much faster than in acidic environments. The degradation of poly(beta-aminoester) with pendant primary amine involves intramolecular/intermolecular amidation and hydrolytic degradation. Under physiological conditions, the intramolecular/intermolecular amidation of poly(beta-aminoester) plays an important role in the polymer degradation. Polymers 1a-1c show significant buffer capacity at pH 4-10. The cytotoxicity of polymer 1a is much higher than that of polymers 1b and 1c.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer - Volume 48, Issue 3, 26 January 2007, Pages 675-681
نویسندگان
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