کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5186322 1381101 2009 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Amphiphilic chitosan nanospheres: Factors to control nanosphere formation and its consequent pH responsive performance
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Amphiphilic chitosan nanospheres: Factors to control nanosphere formation and its consequent pH responsive performance
چکیده انگلیسی

Chitosan grafted with hydrophobic and hydrophilic groups initiates the formation of amphiphilic chitosan nanospheres. The molecular weight of mPEG plays an important role to control the particle size. As compared to mPEG 2000, which gives a bimodal nanosphere (∼200, and ∼300 nm), mPEG 5000 initiates a monodispersed nanosphere with the smaller size (150 nm). In aqueous solution, the nanosphere surface is negatively charged resulting in a well dispersion in neutral to high pH but a significant precipitation in low pH. A model drug incorporation using lidocaine is successful when amphiphilic chitosan nanospheres were dissolved in good solvent followed by allowing mixing with drug solution before dialysis. The particle size of the drug incorporated chitosan is significantly increased, that is, from 100-150 nm to approximately 400-500 nm when the amount of incorporated lidocaine was about 0.68 mg per mg of lidocaine-loaded nanosphere.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer - Volume 50, Issue 8, 9 April 2009, Pages 1877-1886
نویسندگان
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